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Chelerythrine inhibits PKC in a concentration-dependent manner by binding to the catalytic ATP or protein-binding site, and not the regulatory region where DAG or phorbol ester bind (Son et al., 2011), but also anti-inflammatory effects via a pkc mechanism, with pkc acting as an upstream regulator of the pro-inflammatory PKC/NF-kappaB pathway (Zeng et al., 2015)

doi:10.3390/nu12051414 4

These mice have increased systolic blood pressure under anesthesia

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